RNF111-MAPKAP1 Fusion FISH Probe
The RNF111-MAPKAP1 Fusion FISH Probe is used to confirm a fusion of the RNF111 and MAPKAP1 genes. The fusion of the RNF111 and MAPKAP1 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF111-MAPKAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-RERE | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-REOR | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-REGO | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-REGR | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-OROR | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-GORE | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-GROR | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF111-MAPKAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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RNF111 Gene Summary
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Gene Name: Ring Finger Protein 111
Chromosome: CHR15: 59279864 -59389253
Locus: 15q22.1-q22.2
MAPKAP1 Gene Summary
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Associated Protein 1
Chromosome: CHR9: 128199672 -128469513
Locus: 9q33.3
Gene Diseases
The RNF111 MAPKAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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