RNF111-AQP9 Fusion FISH Probe
The RNF111-AQP9 Fusion FISH Probe is used to confirm a fusion of the RNF111 and AQP9 genes. The fusion of the RNF111 and AQP9 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF111-AQP9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-RERE | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-REOR | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-REGO | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-REGR | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-OROR | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-GORE | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-GROR | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF111-AQP9-20-AQAQ | 20 (40 μL) | 200 μL |
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AQP9 Gene Summary
The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability. This protein may also facilitate the uptake of glycerol in hepatic tissue . The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Gene Name: Aquaporin 9
Chromosome: CHR15: 58430407 -58478110
Locus: 15q21.3
RNF111 Gene Summary
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Gene Name: Ring Finger Protein 111
Chromosome: CHR15: 59279864 -59389253
Locus: 15q22.1-q22.2
Gene Diseases
The RNF111 AQP9 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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