RNASEH2A-BEST2 Fusion FISH Probe
The RNASEH2A-BEST2 Fusion FISH Probe is used to confirm a fusion of the RNASEH2A and BEST2 genes. The fusion of the RNASEH2A and BEST2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RNASEH2A-BEST2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| RNASEH2A-BEST2-20-AQAQ | 20 (40 μL) | 200 μL |
|
RNASEH2A Gene Summary
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]
Gene Name: Ribonuclease H2 Subunit A
Chromosome: CHR19: 12917427 -12924462
Locus: 19p13.13
BEST2 Gene Summary
This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008]
Gene Name: Bestrophin 2
Chromosome: CHR19: 12863406 -12869271
Locus: 19p13.13
Gene Diseases
The RNASEH2A BEST2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|