RNASEH1-DYSF Fusion FISH Probe
The RNASEH1-DYSF Fusion FISH Probe is used to confirm a fusion of the RNASEH1 and DYSF genes. The fusion of the RNASEH1 and DYSF genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNASEH1-DYSF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-RERE | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-REOR | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-REGO | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-REGR | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-REAQ | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-ORRE | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-OROR | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-ORGO | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-GORE | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-GOOR | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-GOGO | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-GOGR | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-GRRE | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-GROR | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-GRGO | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-GRGR | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-AQRE | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-AQOR | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-AQGO | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-AQGR | 20 (40 μL) | 200 μL |
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| RNASEH1-DYSF-20-AQAQ | 20 (40 μL) | 200 μL |
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DYSF Gene Summary
The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2008]
Gene Name: Dysferlin
Chromosome: CHR2: 71680752 -71913893
Locus: 2p13.2
RNASEH1 Gene Summary
This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 and 17. [provided by RefSeq, Jul 2017]
Gene Name: Ribonuclease H1
Chromosome: CHR2: 3592690 -3605940
Locus: 2p25.3
Gene Diseases
The RNASEH1 DYSF Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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