RIN3-CCDC88C Fusion FISH Probe
The RIN3-CCDC88C Fusion FISH Probe is used to confirm a fusion of the RIN3 and CCDC88C genes. The fusion of the RIN3 and CCDC88C genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RIN3-CCDC88C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-RERE | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-REOR | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-REGO | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-REGR | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-REAQ | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-ORRE | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-OROR | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-ORGO | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-ORAQ | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-GORE | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-GOOR | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-GOGO | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-GOGR | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-GOAQ | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-GRRE | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-GROR | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-GRGO | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-GRGR | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-GRAQ | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-AQRE | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-AQOR | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-AQGO | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-AQGR | 20 (40 μL) | 200 μL |
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| RIN3-CCDC88C-20-AQAQ | 20 (40 μL) | 200 μL |
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RIN3 Gene Summary
Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: Ras And Rab Interactor 3
Chromosome: CHR14: 92980124 -93155334
Locus: 14q32.12
CCDC88C Gene Summary
This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. [provided by RefSeq, Jan 2013]
Gene Name: Coiled-coil Domain Containing 88C
Chromosome: CHR14: 91737666 -91884188
Locus: 14q32.11-q32.12
Gene Diseases
The RIN3 CCDC88C Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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