RHOT1-FGFR1 Fusion FISH Probe
The RHOT1-FGFR1 Fusion FISH Probe is used to confirm a fusion of the RHOT1 and FGFR1 genes. The fusion of the RHOT1 and FGFR1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RHOT1-FGFR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-RERE | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-REOR | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-REGO | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-REGR | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-REAQ | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-ORRE | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-OROR | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-ORGO | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-GORE | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-GOOR | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-GOGO | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-GOGR | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-GRRE | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-GROR | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-GRGO | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-GRGR | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-AQRE | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-AQOR | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-AQGO | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-AQGR | 20 (40 μL) | 200 μL |
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| RHOT1-FGFR1-20-AQAQ | 20 (40 μL) | 200 μL |
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FGFR1 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Fibroblast Growth Factor Receptor 1
Chromosome: CHR8: 38268655 -38326352
Locus: 8p11.23
RHOT1 Gene Summary
The Ras Homolog Family Member T1 (RHOT1) gene is located on chr17 :30469472-30552746 at 17q11.2.
Gene Name: Ras Homolog Family Member T1
Chromosome: CHR17: 30469472 -30552746
Locus: 17q11.2
Gene Diseases
The RHOT1 FGFR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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