RHOC-DDX21 Fusion FISH Probe
The RHOC-DDX21 Fusion FISH Probe is used to confirm a fusion of the RHOC and DDX21 genes. The fusion of the RHOC and DDX21 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RHOC-DDX21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-RERE | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-REOR | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-REGO | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-REGR | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-REAQ | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-ORRE | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-OROR | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-ORGO | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-ORAQ | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-GORE | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-GOOR | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-GOGO | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-GOGR | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-GOAQ | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-GRRE | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-GROR | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-GRGO | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-GRGR | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-GRAQ | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-AQRE | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-AQOR | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-AQGO | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-AQGR | 20 (40 μL) | 200 μL |
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| RHOC-DDX21-20-AQAQ | 20 (40 μL) | 200 μL |
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RHOC Gene Summary
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Ras Homolog Family Member C
Chromosome: CHR1: 113243748 -113250025
Locus: 1p13.2
DDX21 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
Gene Name: DExD-box Helicase 21
Chromosome: CHR10: 70715891 -70744279
Locus: 10q22.1
Gene Diseases
The RHOC DDX21 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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