RGS6-NPAS3 Fusion FISH Probe
The RGS6-NPAS3 Fusion FISH Probe is used to confirm a fusion of the RGS6 and NPAS3 genes. The fusion of the RGS6 and NPAS3 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RGS6-NPAS3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-RERE | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-REOR | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-REGO | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-REGR | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-REAQ | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-ORRE | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-OROR | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-ORGO | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-ORAQ | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-GORE | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-GOOR | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-GOGO | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-GOGR | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-GOAQ | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-GRRE | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-GROR | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-GRGO | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-GRGR | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-GRAQ | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-AQRE | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-AQOR | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-AQGO | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-AQGR | 20 (40 μL) | 200 μL |
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| RGS6-NPAS3-20-AQAQ | 20 (40 μL) | 200 μL |
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RGS6 Gene Summary
This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
Gene Name: Regulator Of G Protein Signaling 6
Chromosome: CHR14: 72398816 -73033238
Locus: 14q24.2
NPAS3 Gene Summary
This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and cognitive disability. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Name: Neuronal PAS Domain Protein 3
Chromosome: CHR14: 33408458 -34273382
Locus: 14q13.1
Gene Diseases
The RGS6 NPAS3 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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