RGS4-SERPINF2 Fusion FISH Probe
The RGS4-SERPINF2 Fusion FISH Probe is used to confirm a fusion of the RGS4 and SERPINF2 genes. The fusion of the RGS4 and SERPINF2 genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RGS4-SERPINF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-RERE | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-REOR | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-REGO | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-REGR | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-REAQ | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-ORRE | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-OROR | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-ORGO | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-GORE | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-GOOR | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-GOGO | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-GOGR | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-GRRE | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-GROR | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-GRGO | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-GRGR | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-AQRE | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-AQOR | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-AQGO | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-AQGR | 20 (40 μL) | 200 μL |
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| RGS4-SERPINF2-20-AQAQ | 20 (40 μL) | 200 μL |
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SERPINF2 Gene Summary
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Name: Serpin Family F Member 2
Chromosome: CHR17: 1646129 -1658559
Locus: 17p13.3
RGS4 Gene Summary
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Regulator Of G Protein Signaling 4
Chromosome: CHR1: 163038395 -163046592
Locus: 1q23.3
Gene Diseases
The RGS4 SERPINF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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