RGS20-MCPH1 Fusion FISH Probe
The RGS20-MCPH1 Fusion FISH Probe is used to confirm a fusion of the RGS20 and MCPH1 genes. The fusion of the RGS20 and MCPH1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RGS20-MCPH1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-RERE | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-REOR | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-REGO | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-REGR | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-REAQ | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-ORRE | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-OROR | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-ORGO | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-GORE | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-GOOR | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-GOGO | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-GOGR | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-GRRE | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-GROR | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-GRGO | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-GRGR | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-AQRE | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-AQOR | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-AQGO | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-AQGR | 20 (40 μL) | 200 μL |
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| RGS20-MCPH1-20-AQAQ | 20 (40 μL) | 200 μL |
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RGS20 Gene Summary
The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Name: Regulator Of G Protein Signaling 20
Chromosome: CHR8: 54764367 -54871863
Locus: 8q11.23
MCPH1 Gene Summary
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Gene Name: Microcephalin 1
Chromosome: CHR8: 6264112 -6501140
Locus: 8p23.1
Gene Diseases
The RGS20 MCPH1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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