RGS17-PDLIM5 Fusion FISH Probe
The RGS17-PDLIM5 Fusion FISH Probe is used to confirm a fusion of the RGS17 and PDLIM5 genes. The fusion of the RGS17 and PDLIM5 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RGS17-PDLIM5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-RERE | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-REOR | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-REGO | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-REGR | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-REAQ | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-ORRE | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-OROR | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-ORGO | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-ORAQ | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-GORE | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-GOOR | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-GOGO | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-GOGR | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-GOAQ | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-GRRE | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-GROR | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-GRGO | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-GRGR | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-GRAQ | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-AQRE | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-AQOR | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-AQGO | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-AQGR | 20 (40 μL) | 200 μL |
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| RGS17-PDLIM5-20-AQAQ | 20 (40 μL) | 200 μL |
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PDLIM5 Gene Summary
This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: PDZ And LIM Domain 5
Chromosome: CHR4: 95373037 -95589377
Locus: 4q22.3
RGS17 Gene Summary
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Gene Name: Regulator Of G Protein Signaling 17
Chromosome: CHR6: 153332031 -153452389
Locus: 6q25.2
Gene Diseases
The RGS17 PDLIM5 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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