RGS17-LAMA2 Fusion FISH Probe
The RGS17-LAMA2 Fusion FISH Probe is used to confirm a fusion of the RGS17 and LAMA2 genes. The fusion of the RGS17 and LAMA2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RGS17-LAMA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-RERE | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-REOR | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-REGO | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-REGR | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-REAQ | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-ORRE | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-OROR | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-ORGO | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-GORE | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-GOOR | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-GOGO | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-GOGR | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-GRRE | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-GROR | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-GRGO | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-GRGR | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-AQRE | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-AQOR | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-AQGO | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-AQGR | 20 (40 μL) | 200 μL |
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| RGS17-LAMA2-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMA2 Gene Summary
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Laminin Subunit Alpha 2
Chromosome: CHR6: 129204285 -129837710
Locus: 6q22.33
RGS17 Gene Summary
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Gene Name: Regulator Of G Protein Signaling 17
Chromosome: CHR6: 153332031 -153452389
Locus: 6q25.2
Gene Diseases
The RGS17 LAMA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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