RGS12-USP2 Fusion FISH Probe
The RGS12-USP2 Fusion FISH Probe is used to confirm a fusion of the RGS12 and USP2 genes. The fusion of the RGS12 and USP2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RGS12-USP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-RERE | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-REOR | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-REGO | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-REGR | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-REAQ | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-ORRE | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-OROR | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-ORGO | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-GORE | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-GOOR | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-GOGO | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-GOGR | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-GRRE | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-GROR | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-GRGO | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-GRGR | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-AQRE | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-AQOR | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-AQGO | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-AQGR | 20 (40 μL) | 200 μL |
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| RGS12-USP2-20-AQAQ | 20 (40 μL) | 200 μL |
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RGS12 Gene Summary
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Regulator Of G Protein Signaling 12
Chromosome: CHR4: 3315873 -3441640
Locus: 4p16.3
USP2 Gene Summary
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Ubiquitin Specific Peptidase 2
Chromosome: CHR11: 119225924 -119252436
Locus: 11q23.3
Gene Diseases
The RGS12 USP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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