RGS10-TIAL1 Fusion FISH Probe
The RGS10-TIAL1 Fusion FISH Probe is used to confirm a fusion of the RGS10 and TIAL1 genes. The fusion of the RGS10 and TIAL1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RGS10-TIAL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-RERE | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-REOR | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-REGO | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-REGR | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-REAQ | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-ORRE | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-OROR | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-ORGO | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-GORE | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-GOOR | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-GOGO | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-GOGR | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-GRRE | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-GROR | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-GRGO | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-GRGR | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-AQRE | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-AQOR | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-AQGO | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-AQGR | 20 (40 μL) | 200 μL |
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| RGS10-TIAL1-20-AQAQ | 20 (40 μL) | 200 μL |
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RGS10 Gene Summary
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Regulator Of G Protein Signaling 10
Chromosome: CHR10: 121259338 -121302222
Locus: 10q26.11
TIAL1 Gene Summary
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
Gene Name: TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1
Chromosome: CHR10: 121332977 -121356541
Locus: 10q26.11
Gene Diseases
The RGS10 TIAL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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