RFXAP-SMAD9 Fusion FISH Probe
The RFXAP-SMAD9 Fusion FISH Probe is used to confirm a fusion of the RFXAP and SMAD9 genes. The fusion of the RFXAP and SMAD9 genes has been associated with Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RFXAP-SMAD9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-RERE | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-REOR | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-REGO | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-REGR | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-REAQ | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-ORRE | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-OROR | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-ORGO | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-ORAQ | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-GORE | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-GOOR | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-GOGO | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-GOGR | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-GOAQ | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-GRRE | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-GROR | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-GRGO | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-GRGR | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-GRAQ | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-AQRE | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-AQOR | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-AQGO | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-AQGR | 20 (40 μL) | 200 μL |
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| RFXAP-SMAD9-20-AQAQ | 20 (40 μL) | 200 μL |
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SMAD9 Gene Summary
The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Gene Name: SMAD Family Member 9
Chromosome: CHR13: 37418967 -37494409
Locus: 13q13.3
RFXAP Gene Summary
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Regulatory Factor X Associated Protein
Chromosome: CHR13: 37393338 -37403740
Locus: 13q13.3
Gene Diseases
The RFXAP SMAD9 Fusion has been associated with the following diseases:
| Disease Name |
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| Lymphoid Neoplasm Diffuse Large B-cell Lymphoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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