RFX7-PCSK6 Fusion FISH Probe
The RFX7-PCSK6 Fusion FISH Probe is used to confirm a fusion of the RFX7 and PCSK6 genes. The fusion of the RFX7 and PCSK6 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RFX7-PCSK6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-RERE | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-REOR | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-REGO | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-REGR | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-REAQ | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-ORRE | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-OROR | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-ORGO | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-ORAQ | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-GORE | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-GOOR | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-GOGO | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-GOGR | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-GOAQ | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-GRRE | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-GROR | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-GRGO | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-GRGR | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-GRAQ | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-AQRE | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-AQOR | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-AQGO | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-AQGR | 20 (40 μL) | 200 μL |
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| RFX7-PCSK6-20-AQAQ | 20 (40 μL) | 200 μL |
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PCSK6 Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]
Gene Name: Proprotein Convertase Subtilisin/kexin Type 6
Chromosome: CHR15: 101844132 -102030187
Locus: 15q26.3
RFX7 Gene Summary
RFX7 is a member of the regulatory factor X (RFX) family of transcription factors (see RFX1, MIM 600006) (Aftab et al., 2008 [PubMed 18673564]).[supplied by OMIM, Mar 2009]
Gene Name: Regulatory Factor X7
Chromosome: CHR15: 56382730 -56535483
Locus: 15q21.3
Gene Diseases
The RFX7 PCSK6 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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