RFC4-EHHADH Fusion FISH Probe
The RFC4-EHHADH Fusion FISH Probe is used to confirm a fusion of the RFC4 and EHHADH genes. The fusion of the RFC4 and EHHADH genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RFC4-EHHADH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-RERE | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-REOR | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-REGO | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-REGR | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-REAQ | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-ORRE | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-OROR | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-ORGO | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-ORAQ | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-GORE | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-GOOR | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-GOGO | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-GOGR | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-GOAQ | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-GRRE | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-GROR | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-GRGO | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-GRGR | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-GRAQ | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-AQRE | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-AQOR | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-AQGO | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-AQGR | 20 (40 μL) | 200 μL |
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| RFC4-EHHADH-20-AQAQ | 20 (40 μL) | 200 μL |
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EHHADH Gene Summary
The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Name: Enoyl-CoA Hydratase And 3-hydroxyacyl CoA Dehydrogenase
Chromosome: CHR3: 184908411 -184971886
Locus: 3q27.2
RFC4 Gene Summary
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Replication Factor C Subunit 4
Chromosome: CHR3: 186507681 -186524484
Locus: 3q27.3
Gene Diseases
The RFC4 EHHADH Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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