RFC1-CORIN Fusion FISH Probe
The RFC1-CORIN Fusion FISH Probe is used to confirm a fusion of the RFC1 and CORIN genes. The fusion of the RFC1 and CORIN genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RFC1-CORIN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-RERE | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-REOR | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-REGO | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-REGR | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-REAQ | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-ORRE | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-OROR | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-ORGO | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-ORAQ | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-GORE | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-GOOR | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-GOGO | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-GOGR | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-GOAQ | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-GRRE | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-GROR | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-GRGO | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-GRGR | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-GRAQ | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-AQRE | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-AQOR | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-AQGO | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-AQGR | 20 (40 μL) | 200 μL |
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| RFC1-CORIN-20-AQAQ | 20 (40 μL) | 200 μL |
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RFC1 Gene Summary
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
Gene Name: Replication Factor C Subunit 1
Chromosome: CHR4: 39289068 -39368001
Locus: 4p14
CORIN Gene Summary
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Gene Name: Corin, Serine Peptidase
Chromosome: CHR4: 47596017 -47840059
Locus: 4p12
Gene Diseases
The RFC1 CORIN Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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