REV3L-TRAF3IP2 Fusion FISH Probe
The REV3L-TRAF3IP2 Fusion FISH Probe is used to confirm a fusion of the REV3L and TRAF3IP2 genes. The fusion of the REV3L and TRAF3IP2 genes has been associated with Sarcoma, and Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| REV3L-TRAF3IP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-RERE | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-REOR | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-REGO | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-REGR | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-REAQ | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-ORRE | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-OROR | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-ORGO | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-GORE | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-GOOR | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-GOGO | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-GOGR | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-GRRE | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-GROR | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-GRGO | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-GRGR | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-AQRE | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-AQOR | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-AQGO | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-AQGR | 20 (40 μL) | 200 μL |
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| REV3L-TRAF3IP2-20-AQAQ | 20 (40 μL) | 200 μL |
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REV3L Gene Summary
The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017]
Gene Name: REV3 Like, DNA Directed Polymerase Zeta Catalytic Subunit
Chromosome: CHR6: 111620233 -111804414
Locus: 6q21
TRAF3IP2 Gene Summary
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]
Gene Name: TRAF3 Interacting Protein 2
Chromosome: CHR6: 111880142 -111927474
Locus: 6q21
Gene Diseases
The REV3L TRAF3IP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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