REV3L-LAMA4 Fusion FISH Probe
The REV3L-LAMA4 Fusion FISH Probe is used to confirm a fusion of the REV3L and LAMA4 genes. The fusion of the REV3L and LAMA4 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| REV3L-LAMA4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-RERE | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-REOR | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-REGO | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-REGR | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-REAQ | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-ORRE | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-OROR | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-ORGO | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-ORAQ | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-GORE | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-GOOR | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-GOGO | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-GOGR | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-GOAQ | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-GRRE | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-GROR | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-GRGO | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-GRGR | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-GRAQ | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-AQRE | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-AQOR | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-AQGO | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-AQGR | 20 (40 μL) | 200 μL |
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| REV3L-LAMA4-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMA4 Gene Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
Gene Name: Laminin Subunit Alpha 4
Chromosome: CHR6: 112429133 -112575828
Locus: 6q21
REV3L Gene Summary
The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017]
Gene Name: REV3 Like, DNA Directed Polymerase Zeta Catalytic Subunit
Chromosome: CHR6: 111620233 -111804414
Locus: 6q21
Gene Diseases
The REV3L LAMA4 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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