REV3L-FYN Fusion FISH Probe
The REV3L-FYN Fusion FISH Probe is used to confirm a fusion of the REV3L and FYN genes. The fusion of the REV3L and FYN genes has been associated with Breast Invasive Carcinoma, Uterine Corpus Endometrial Carcinoma, Skin Cutaneous Melanoma, Uterine Carcinosarcoma, and Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| REV3L-FYN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-RERE | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-REOR | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-REGO | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-REGR | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-REAQ | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-ORRE | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-OROR | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-ORGO | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-ORAQ | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-GORE | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-GOOR | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-GOGO | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-GOGR | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-GOAQ | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-GRRE | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-GROR | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-GRGO | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-GRGR | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-GRAQ | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-AQRE | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-AQOR | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-AQGO | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-AQGR | 20 (40 μL) | 200 μL |
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| REV3L-FYN-20-AQAQ | 20 (40 μL) | 200 μL |
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FYN Gene Summary
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
Gene Name: FYN Proto-oncogene, Src Family Tyrosine Kinase
Chromosome: CHR6: 111981534 -112194655
Locus: 6q21
REV3L Gene Summary
The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017]
Gene Name: REV3 Like, DNA Directed Polymerase Zeta Catalytic Subunit
Chromosome: CHR6: 111620233 -111804414
Locus: 6q21
Gene Diseases
The REV3L FYN Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Skin Cutaneous Melanoma |
| Uterine Carcinosarcoma |
| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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