REV1-AFF3 Fusion FISH Probe
The REV1-AFF3 Fusion FISH Probe is used to confirm a fusion of the REV1 and AFF3 genes. The fusion of the REV1 and AFF3 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| REV1-AFF3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-RERE | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-REOR | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-REGO | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-REGR | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-REAQ | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-ORRE | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-OROR | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-ORGO | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-ORAQ | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-GORE | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-GOOR | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-GOGO | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-GOGR | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-GOAQ | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-GRRE | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-GROR | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-GRGO | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-GRGR | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-GRAQ | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-AQRE | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-AQOR | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-AQGO | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-AQGR | 20 (40 μL) | 200 μL |
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| REV1-AFF3-20-AQAQ | 20 (40 μL) | 200 μL |
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AFF3 Gene Summary
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: AF4/FMR2 Family Member 3
Chromosome: CHR2: 100163715 -100759037
Locus: 2q11.2
REV1 Gene Summary
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]
Gene Name: REV1, DNA Directed Polymerase
Chromosome: CHR2: 100016937 -100106480
Locus: 2q11.2
Gene Diseases
The REV1 AFF3 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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