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RET-CCDC6 Fusion FISH Probe

The RET-CCDC6 Fusion FISH Probe is used to confirm a fusion of the RET and CCDC6 genes. The fusion of the RET and CCDC6 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
RET-CCDC6-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
RET-CCDC6-20-RERE 20 (40 μL) 200 μL
RET-CCDC6-20-REOR 20 (40 μL) 200 μL
RET-CCDC6-20-REGO 20 (40 μL) 200 μL
RET-CCDC6-20-REGR 20 (40 μL) 200 μL
RET-CCDC6-20-REAQ 20 (40 μL) 200 μL
RET-CCDC6-20-ORRE 20 (40 μL) 200 μL
RET-CCDC6-20-OROR 20 (40 μL) 200 μL
RET-CCDC6-20-ORGO 20 (40 μL) 200 μL
RET-CCDC6-20-ORAQ 20 (40 μL) 200 μL
RET-CCDC6-20-GORE 20 (40 μL) 200 μL
RET-CCDC6-20-GOOR 20 (40 μL) 200 μL
RET-CCDC6-20-GOGO 20 (40 μL) 200 μL
RET-CCDC6-20-GOGR 20 (40 μL) 200 μL
RET-CCDC6-20-GOAQ 20 (40 μL) 200 μL
RET-CCDC6-20-GRRE 20 (40 μL) 200 μL
RET-CCDC6-20-GROR 20 (40 μL) 200 μL
RET-CCDC6-20-GRGO 20 (40 μL) 200 μL
RET-CCDC6-20-GRGR 20 (40 μL) 200 μL
RET-CCDC6-20-GRAQ 20 (40 μL) 200 μL
RET-CCDC6-20-AQRE 20 (40 μL) 200 μL
RET-CCDC6-20-AQOR 20 (40 μL) 200 μL
RET-CCDC6-20-AQGO 20 (40 μL) 200 μL
RET-CCDC6-20-AQGR 20 (40 μL) 200 μL
RET-CCDC6-20-AQAQ 20 (40 μL) 200 μL

RET Gene Summary

This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]

Gene Name: Ret Proto-oncogene

Chromosome: CHR10: 43572516 -43625797

Locus: 10q11.21

CCDC6 Gene Summary

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]

Gene Name: Coiled-coil Domain Containing 6

Chromosome: CHR10: 61548505 -61666414

Locus: 10q21.2

Gene Diseases

The RET CCDC6 Fusion has been associated with the following diseases:

Disease Name
Thyroid Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.