RET-ANK3 Fusion FISH Probe
The RET-ANK3 Fusion FISH Probe is used to confirm a fusion of the RET and ANK3 genes. The fusion of the RET and ANK3 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RET-ANK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-RERE | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-REOR | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-REGO | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-REGR | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-REAQ | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-ORRE | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-OROR | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-ORGO | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-GORE | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-GOOR | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-GOGO | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-GOGR | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-GRRE | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-GROR | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-GRGO | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-GRGR | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-AQRE | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-AQOR | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-AQGO | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-AQGR | 20 (40 μL) | 200 μL |
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| RET-ANK3-20-AQAQ | 20 (40 μL) | 200 μL |
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ANK3 Gene Summary
Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Name: Ankyrin 3
Chromosome: CHR10: 61786055 -62493284
Locus: 10q21.2
RET Gene Summary
This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]
Gene Name: Ret Proto-oncogene
Chromosome: CHR10: 43572516 -43625797
Locus: 10q11.21
Gene Diseases
The RET ANK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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