RBM17-PSAP Fusion FISH Probe
The RBM17-PSAP Fusion FISH Probe is used to confirm a fusion of the RBM17 and PSAP genes. The fusion of the RBM17 and PSAP genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RBM17-PSAP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-RERE | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-REOR | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-REGO | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-REGR | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-REAQ | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-ORRE | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-OROR | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-ORGO | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-ORAQ | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-GORE | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-GOOR | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-GOGO | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-GOGR | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-GOAQ | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-GRRE | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-GROR | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-GRGO | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-GRGR | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-GRAQ | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-AQRE | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-AQOR | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-AQGO | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-AQGR | 20 (40 μL) | 200 μL |
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| RBM17-PSAP-20-AQAQ | 20 (40 μL) | 200 μL |
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PSAP Gene Summary
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Prosaposin
Chromosome: CHR10: 73576054 -73611082
Locus: 10q22.1
RBM17 Gene Summary
This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15. [provided by RefSeq, Mar 2009]
Gene Name: RNA Binding Motif Protein 17
Chromosome: CHR10: 6130948 -6159422
Locus: 10p15.1
Gene Diseases
The RBM17 PSAP Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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