RBL1-BCAS1 Fusion FISH Probe
The RBL1-BCAS1 Fusion FISH Probe is used to confirm a fusion of the RBL1 and BCAS1 genes. The fusion of the RBL1 and BCAS1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RBL1-BCAS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-RERE | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-REOR | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-REGO | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-REGR | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-REAQ | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-ORRE | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-OROR | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-ORGO | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-GORE | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-GOOR | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-GOGO | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-GOGR | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-GRRE | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-GROR | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-GRGO | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-GRGR | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-AQRE | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-AQOR | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-AQGO | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-AQGR | 20 (40 μL) | 200 μL |
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| RBL1-BCAS1-20-AQAQ | 20 (40 μL) | 200 μL |
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RBL1 Gene Summary
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: RB Transcriptional Corepressor Like 1
Chromosome: CHR20: 35626177 -35724410
Locus: 20q11.23
BCAS1 Gene Summary
This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene. [provided by RefSeq, Apr 2016]
Gene Name: Breast Carcinoma Amplified Sequence 1
Chromosome: CHR20: 52560078 -52687304
Locus: 20q13.2
Gene Diseases
The RBL1 BCAS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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