RB1-MED4 Fusion FISH Probe
The RB1-MED4 Fusion FISH Probe is used to confirm a fusion of the RB1 and MED4 genes. The fusion of the RB1 and MED4 genes has been associated with Skin Cutaneous Melanoma, and Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RB1-MED4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-RERE | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-REOR | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-REGO | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-REGR | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-OROR | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-GORE | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-GROR | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| RB1-MED4-20-AQAQ | 20 (40 μL) | 200 μL |
|
RB1 Gene Summary
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Gene Name: RB Transcriptional Corepressor 1
Chromosome: CHR13: 48877882 -49056026
Locus: 13q14.2
MED4 Gene Summary
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Mediator Complex Subunit 4
Chromosome: CHR13: 48650091 -48669240
Locus: 13q14.2
Gene Diseases
The RB1 MED4 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|