RB1-HTR2C Fusion FISH Probe
The RB1-HTR2C Fusion FISH Probe is used to confirm a fusion of the RB1 and HTR2C genes. The fusion of the RB1 and HTR2C genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RB1-HTR2C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-RERE | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-REOR | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-REGO | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-REGR | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-REAQ | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-ORRE | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-OROR | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-ORGO | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-ORAQ | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-GORE | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-GOOR | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-GOGO | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-GOGR | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-GOAQ | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-GRRE | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-GROR | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-GRGO | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-GRGR | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-GRAQ | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-AQRE | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-AQOR | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-AQGO | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-AQGR | 20 (40 μL) | 200 μL |
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| RB1-HTR2C-20-AQAQ | 20 (40 μL) | 200 μL |
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HTR2C Gene Summary
This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: 5-hydroxytryptamine Receptor 2C
Chromosome: CHRX: 113818550 -114144624
Locus: Xq23
RB1 Gene Summary
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Gene Name: RB Transcriptional Corepressor 1
Chromosome: CHR13: 48877882 -49056026
Locus: 13q14.2
Gene Diseases
The RB1 HTR2C Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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