RB1-ESR2 Fusion FISH Probe
The RB1-ESR2 Fusion FISH Probe is used to confirm a fusion of the RB1 and ESR2 genes. The fusion of the RB1 and ESR2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RB1-ESR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-RERE | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-REOR | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-REGO | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-REGR | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-REAQ | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-ORRE | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-OROR | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-ORGO | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-GORE | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-GOOR | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-GOGO | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-GOGR | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-GRRE | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-GROR | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-GRGO | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-GRGR | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-AQRE | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-AQOR | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-AQGO | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-AQGR | 20 (40 μL) | 200 μL |
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| RB1-ESR2-20-AQAQ | 20 (40 μL) | 200 μL |
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ESR2 Gene Summary
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Estrogen Receptor 2
Chromosome: CHR14: 64693750 -64805268
Locus: 14q23.2-q23.3
RB1 Gene Summary
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Gene Name: RB Transcriptional Corepressor 1
Chromosome: CHR13: 48877882 -49056026
Locus: 13q14.2
Gene Diseases
The RB1 ESR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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