RB1-CLEC2B Fusion FISH Probe
The RB1-CLEC2B Fusion FISH Probe is used to confirm a fusion of the RB1 and CLEC2B genes. The fusion of the RB1 and CLEC2B genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RB1-CLEC2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-RERE | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-REOR | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-REGO | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-REGR | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-REAQ | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-ORRE | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-OROR | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-ORGO | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-GORE | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-GOOR | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-GOGO | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-GOGR | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-GRRE | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-GROR | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-GRGO | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-GRGR | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-AQRE | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-AQOR | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-AQGO | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-AQGR | 20 (40 μL) | 200 μL |
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| RB1-CLEC2B-20-AQAQ | 20 (40 μL) | 200 μL |
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RB1 Gene Summary
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Gene Name: RB Transcriptional Corepressor 1
Chromosome: CHR13: 48877882 -49056026
Locus: 13q14.2
CLEC2B Gene Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Gene Name: C-type Lectin Domain Family 2 Member B
Chromosome: CHR12: 10004967 -10022458
Locus: 12p13.31
Gene Diseases
The RB1 CLEC2B Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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