RASSF3-TBK1 Fusion FISH Probe
The RASSF3-TBK1 Fusion FISH Probe is used to confirm a fusion of the RASSF3 and TBK1 genes. The fusion of the RASSF3 and TBK1 genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RASSF3-TBK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-RERE | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-REOR | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-REGO | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-REGR | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-REAQ | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-ORRE | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-OROR | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-ORGO | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-GORE | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-GOOR | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-GOGO | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-GOGR | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-GRRE | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-GROR | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-GRGO | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-GRGR | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-AQRE | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-AQOR | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-AQGO | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-AQGR | 20 (40 μL) | 200 μL |
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| RASSF3-TBK1-20-AQAQ | 20 (40 μL) | 200 μL |
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TBK1 Gene Summary
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010]
Gene Name: TANK Binding Kinase 1
Chromosome: CHR12: 64845839 -64895899
Locus: 12q14.2
RASSF3 Gene Summary
The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM, Jul 2003]
Gene Name: Ras Association Domain Family Member 3
Chromosome: CHR12: 65004292 -65091347
Locus: 12q14.2
Gene Diseases
The RASSF3 TBK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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