RASD1-VPS4A Fusion FISH Probe
The RASD1-VPS4A Fusion FISH Probe is used to confirm a fusion of the RASD1 and VPS4A genes. The fusion of the RASD1 and VPS4A genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RASD1-VPS4A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-RERE | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-REOR | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-REGO | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-REGR | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-REAQ | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-ORRE | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-OROR | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-ORGO | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-ORAQ | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-GORE | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-GOOR | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-GOGO | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-GOGR | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-GOAQ | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-GRRE | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-GROR | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-GRGO | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-GRGR | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-GRAQ | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-AQRE | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-AQOR | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-AQGO | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-AQGR | 20 (40 μL) | 200 μL |
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| RASD1-VPS4A-20-AQAQ | 20 (40 μL) | 200 μL |
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VPS4A Gene Summary
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008]
Gene Name: Vacuolar Protein Sorting 4 Homolog A
Chromosome: CHR16: 69345286 -69358946
Locus: 16q22.1
RASD1 Gene Summary
This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]
Gene Name: Ras Related Dexamethasone Induced 1
Chromosome: CHR17: 17397752 -17399709
Locus: 17p11.2
Gene Diseases
The RASD1 VPS4A Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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