RASAL2-KIF14 Fusion FISH Probe
The RASAL2-KIF14 Fusion FISH Probe is used to confirm a fusion of the RASAL2 and KIF14 genes. The fusion of the RASAL2 and KIF14 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RASAL2-KIF14-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-RERE | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-REOR | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-REGO | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-REGR | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-REAQ | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-ORRE | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-OROR | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-ORGO | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-ORAQ | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-GORE | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-GOOR | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-GOGO | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-GOGR | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-GOAQ | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-GRRE | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-GROR | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-GRGO | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-GRGR | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-GRAQ | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-AQRE | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-AQOR | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-AQGO | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-AQGR | 20 (40 μL) | 200 μL |
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| RASAL2-KIF14-20-AQAQ | 20 (40 μL) | 200 μL |
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RASAL2 Gene Summary
This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: RAS Protein Activator Like 2
Chromosome: CHR1: 178062863 -178448648
Locus: 1q25.2
KIF14 Gene Summary
This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Gene Name: Kinesin Family Member 14
Chromosome: CHR1: 200520624 -200589862
Locus: 1q32.1
Gene Diseases
The RASAL2 KIF14 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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