RASAL2-COPA Fusion FISH Probe
The RASAL2-COPA Fusion FISH Probe is used to confirm a fusion of the RASAL2 and COPA genes. The fusion of the RASAL2 and COPA genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RASAL2-COPA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-RERE | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-REOR | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-REGO | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-REGR | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-REAQ | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-ORRE | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-OROR | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-ORGO | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-ORAQ | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-GORE | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-GOOR | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-GOGO | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-GOGR | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-GOAQ | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-GRRE | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-GROR | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-GRGO | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-GRGR | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-GRAQ | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-AQRE | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-AQOR | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-AQGO | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-AQGR | 20 (40 μL) | 200 μL |
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| RASAL2-COPA-20-AQAQ | 20 (40 μL) | 200 μL |
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COPA Gene Summary
In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Coatomer Protein Complex Subunit Alpha
Chromosome: CHR1: 160258376 -160313354
Locus: 1q23.2
RASAL2 Gene Summary
This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: RAS Protein Activator Like 2
Chromosome: CHR1: 178062863 -178448648
Locus: 1q25.2
Gene Diseases
The RASAL2 COPA Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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