RASAL1-DDX54 Fusion FISH Probe
The RASAL1-DDX54 Fusion FISH Probe is used to confirm a fusion of the RASAL1 and DDX54 genes. The fusion of the RASAL1 and DDX54 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RASAL1-DDX54-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-RERE | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-REOR | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-REGO | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-REGR | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-REAQ | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-ORRE | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-OROR | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-ORGO | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-ORAQ | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-GORE | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-GOOR | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-GOGO | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-GOGR | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-GOAQ | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-GRRE | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-GROR | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-GRGO | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-GRGR | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-GRAQ | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-AQRE | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-AQOR | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-AQGO | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-AQGR | 20 (40 μL) | 200 μL |
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| RASAL1-DDX54-20-AQAQ | 20 (40 μL) | 200 μL |
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RASAL1 Gene Summary
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]
Gene Name: RAS Protein Activator Like 1
Chromosome: CHR12: 113536623 -113574044
Locus: 12q24.13
DDX54 Gene Summary
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: DEAD-box Helicase 54
Chromosome: CHR12: 113594977 -113623284
Locus: 12q24.13
Gene Diseases
The RASAL1 DDX54 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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