RASA1-CDH12 Fusion FISH Probe
The RASA1-CDH12 Fusion FISH Probe is used to confirm a fusion of the RASA1 and CDH12 genes. The fusion of the RASA1 and CDH12 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RASA1-CDH12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-RERE | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-REOR | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-REGO | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-REGR | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-REAQ | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-ORRE | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-OROR | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-ORGO | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-ORAQ | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-GORE | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-GOOR | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-GOGO | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-GOGR | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-GOAQ | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-GRRE | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-GROR | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-GRGO | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-GRGR | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-GRAQ | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-AQRE | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-AQOR | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-AQGO | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-AQGR | 20 (40 μL) | 200 μL |
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| RASA1-CDH12-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH12 Gene Summary
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015]
Gene Name: Cadherin 12
Chromosome: CHR5: 21750972 -22853731
Locus: 5p14.3
RASA1 Gene Summary
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]
Gene Name: RAS P21 Protein Activator 1
Chromosome: CHR5: 86564150 -86687733
Locus: 5q14.3
Gene Diseases
The RASA1 CDH12 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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