RARB-PRDM8 Fusion FISH Probe
The RARB-PRDM8 Fusion FISH Probe is used to confirm a fusion of the RARB and PRDM8 genes. The fusion of the RARB and PRDM8 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RARB-PRDM8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-RERE | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-REOR | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-REGO | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-REGR | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-REAQ | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-ORRE | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-OROR | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-ORGO | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-ORAQ | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-GORE | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-GOOR | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-GOGO | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-GOGR | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-GOAQ | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-GRRE | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-GROR | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-GRGO | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-GRGR | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-GRAQ | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-AQRE | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-AQOR | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-AQGO | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-AQGR | 20 (40 μL) | 200 μL |
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| RARB-PRDM8-20-AQAQ | 20 (40 μL) | 200 μL |
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RARB Gene Summary
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Name: Retinoic Acid Receptor Beta
Chromosome: CHR3: 25469753 -25639422
Locus: 3p24.2
PRDM8 Gene Summary
This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: PR/SET Domain 8
Chromosome: CHR4: 81106423 -81125482
Locus: 4q21.21
Gene Diseases
The RARB PRDM8 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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