RARA-PML Fusion FISH Probe
The RARA-PML Fusion FISH Probe is used to confirm a fusion of the RARA and PML genes. The fusion of the RARA and PML genes has been associated with Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia, and Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RARA-PML-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RARA-PML-20-RERE | 20 (40 μL) | 200 μL |
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| RARA-PML-20-REOR | 20 (40 μL) | 200 μL |
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| RARA-PML-20-REGO | 20 (40 μL) | 200 μL |
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| RARA-PML-20-REGR | 20 (40 μL) | 200 μL |
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| RARA-PML-20-REAQ | 20 (40 μL) | 200 μL |
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| RARA-PML-20-ORRE | 20 (40 μL) | 200 μL |
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| RARA-PML-20-OROR | 20 (40 μL) | 200 μL |
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| RARA-PML-20-ORGO | 20 (40 μL) | 200 μL |
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| RARA-PML-20-ORAQ | 20 (40 μL) | 200 μL |
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| RARA-PML-20-GORE | 20 (40 μL) | 200 μL |
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| RARA-PML-20-GOOR | 20 (40 μL) | 200 μL |
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| RARA-PML-20-GOGO | 20 (40 μL) | 200 μL |
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| RARA-PML-20-GOGR | 20 (40 μL) | 200 μL |
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| RARA-PML-20-GOAQ | 20 (40 μL) | 200 μL |
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| RARA-PML-20-GRRE | 20 (40 μL) | 200 μL |
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| RARA-PML-20-GROR | 20 (40 μL) | 200 μL |
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| RARA-PML-20-GRGO | 20 (40 μL) | 200 μL |
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| RARA-PML-20-GRGR | 20 (40 μL) | 200 μL |
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| RARA-PML-20-GRAQ | 20 (40 μL) | 200 μL |
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| RARA-PML-20-AQRE | 20 (40 μL) | 200 μL |
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| RARA-PML-20-AQOR | 20 (40 μL) | 200 μL |
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| RARA-PML-20-AQGO | 20 (40 μL) | 200 μL |
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| RARA-PML-20-AQGR | 20 (40 μL) | 200 μL |
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| RARA-PML-20-AQAQ | 20 (40 μL) | 200 μL |
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PML Gene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Promyelocytic Leukemia
Chromosome: CHR15: 74287013 -74340155
Locus: 15q24.1
RARA Gene Summary
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
Gene Name: Retinoic Acid Receptor Alpha
Chromosome: CHR17: 38465422 -38513895
Locus: 17q21.2
Gene Diseases
The RARA PML Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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