RARA-HOXB3 Fusion FISH Probe
The RARA-HOXB3 Fusion FISH Probe is used to confirm a fusion of the RARA and HOXB3 genes. The fusion of the RARA and HOXB3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RARA-HOXB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-RERE | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-REOR | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-REGO | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-REGR | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-REAQ | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-ORRE | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-OROR | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-ORGO | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-GORE | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-GOOR | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-GOGO | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-GOGR | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-GRRE | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-GROR | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-GRGO | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-GRGR | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-AQRE | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-AQOR | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-AQGO | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-AQGR | 20 (40 μL) | 200 μL |
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| RARA-HOXB3-20-AQAQ | 20 (40 μL) | 200 μL |
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HOXB3 Gene Summary
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]
Gene Name: Homeobox B3
Chromosome: CHR17: 46626231 -46651810
Locus: 17q21.32
RARA Gene Summary
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
Gene Name: Retinoic Acid Receptor Alpha
Chromosome: CHR17: 38465422 -38513895
Locus: 17q21.2
Gene Diseases
The RARA HOXB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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