RAPGEF5-BAALC Fusion FISH Probe
The RAPGEF5-BAALC Fusion FISH Probe is used to confirm a fusion of the RAPGEF5 and BAALC genes. The fusion of the RAPGEF5 and BAALC genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAPGEF5-BAALC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-RERE | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-REOR | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-REGO | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-REGR | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-REAQ | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-ORRE | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-OROR | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-ORGO | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-GORE | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-GOOR | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-GOGO | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-GOGR | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-GRRE | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-GROR | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-GRGO | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-GRGR | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-AQRE | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-AQOR | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-AQGO | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-AQGR | 20 (40 μL) | 200 μL |
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| RAPGEF5-BAALC-20-AQAQ | 20 (40 μL) | 200 μL |
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RAPGEF5 Gene Summary
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Gene Name: Rap Guanine Nucleotide Exchange Factor 5
Chromosome: CHR7: 22157907 -22396533
Locus: 7p15.3
BAALC Gene Summary
This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML). The gene is conserved among mammals and is not found in lower organisms. Tissues that express this gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines. [provided by RefSeq, Jul 2008]
Gene Name: BAALC, MAP3K1 And KLF4 Binding
Chromosome: CHR8: 104152920 -104242533
Locus: 8q22.3
Gene Diseases
The RAPGEF5 BAALC Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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