RAPGEF1-ZMYND19 Fusion FISH Probe
The RAPGEF1-ZMYND19 Fusion FISH Probe is used to confirm a fusion of the RAPGEF1 and ZMYND19 genes. The fusion of the RAPGEF1 and ZMYND19 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAPGEF1-ZMYND19-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-RERE | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-REOR | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-REGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-REGR | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-REAQ | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-ORRE | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-OROR | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-ORGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-GORE | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-GOOR | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-GOGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-GOGR | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-GRRE | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-GROR | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-GRGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-GRGR | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-AQRE | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-AQOR | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-AQGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-AQGR | 20 (40 μL) | 200 μL |
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| RAPGEF1-ZMYND19-20-AQAQ | 20 (40 μL) | 200 μL |
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RAPGEF1 Gene Summary
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Rap Guanine Nucleotide Exchange Factor 1
Chromosome: CHR9: 134452156 -134612925
Locus: 9q34.13
ZMYND19 Gene Summary
ZMYND19 is a MYND zinc finger domain-containing protein that binds to the C terminus of melanin-concentrating hormone receptor-1 (MCHR1; MIM 601751) (Bachner et al., 2002 [PubMed 12208518]), and to the N termini of alpha-tubulin (TUBA1; MIM 191110), and beta-tubulin (TUBB; MIM 191130) (Francke et al., 2005 [PubMed 16039987]).[supplied by OMIM, Mar 2008]
Gene Name: Zinc Finger MYND-type Containing 19
Chromosome: CHR9: 140476530 -140484937
Locus: 9q34.3
Gene Diseases
The RAPGEF1 ZMYND19 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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