RAPGEF1-TTF1 Fusion FISH Probe
The RAPGEF1-TTF1 Fusion FISH Probe is used to confirm a fusion of the RAPGEF1 and TTF1 genes. The fusion of the RAPGEF1 and TTF1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAPGEF1-TTF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-RERE | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-REOR | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-REGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-REGR | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-REAQ | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-ORRE | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-OROR | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-ORGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-GORE | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-GOOR | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-GOGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-GOGR | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-GRRE | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-GROR | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-GRGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-GRGR | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-AQRE | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-AQOR | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-AQGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-AQGR | 20 (40 μL) | 200 μL |
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| RAPGEF1-TTF1-20-AQAQ | 20 (40 μL) | 200 μL |
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RAPGEF1 Gene Summary
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Rap Guanine Nucleotide Exchange Factor 1
Chromosome: CHR9: 134452156 -134612925
Locus: 9q34.13
TTF1 Gene Summary
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]
Gene Name: Transcription Termination Factor 1
Chromosome: CHR9: 135250936 -135282238
Locus: 9q34.13
Gene Diseases
The RAPGEF1 TTF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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