RAPGEF1-MED27 Fusion FISH Probe
The RAPGEF1-MED27 Fusion FISH Probe is used to confirm a fusion of the RAPGEF1 and MED27 genes. The fusion of the RAPGEF1 and MED27 genes has been associated with Head And Neck Squamous Cell Carcinoma , and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAPGEF1-MED27-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-RERE | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-REOR | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-REGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-REGR | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-REAQ | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-ORRE | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-OROR | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-ORGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-GORE | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-GOOR | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-GOGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-GOGR | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-GRRE | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-GROR | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-GRGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-GRGR | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-AQRE | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-AQOR | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-AQGO | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-AQGR | 20 (40 μL) | 200 μL |
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| RAPGEF1-MED27-20-AQAQ | 20 (40 μL) | 200 μL |
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RAPGEF1 Gene Summary
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Rap Guanine Nucleotide Exchange Factor 1
Chromosome: CHR9: 134452156 -134612925
Locus: 9q34.13
MED27 Gene Summary
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
Gene Name: Mediator Complex Subunit 27
Chromosome: CHR9: 134735498 -134955253
Locus: 9q34.13
Gene Diseases
The RAPGEF1 MED27 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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