RAP1GAP-USP48 Fusion FISH Probe
The RAP1GAP-USP48 Fusion FISH Probe is used to confirm a fusion of the RAP1GAP and USP48 genes. The fusion of the RAP1GAP and USP48 genes has been associated with Breast Invasive Carcinoma, and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RAP1GAP-USP48-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-RERE | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-REOR | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-REGO | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-REGR | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-OROR | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-GORE | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-GROR | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| RAP1GAP-USP48-20-AQAQ | 20 (40 μL) | 200 μL |
|
RAP1GAP Gene Summary
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Gene Name: RAP1 GTPase Activating Protein
Chromosome: CHR1: 21922707 -21995856
Locus: 1p36.12
USP48 Gene Summary
This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Specific Peptidase 48
Chromosome: CHR1: 22004791 -22109688
Locus: 1p36.12
Gene Diseases
The RAP1GAP USP48 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|