RAP1GAP-CELA3B Fusion FISH Probe
The RAP1GAP-CELA3B Fusion FISH Probe is used to confirm a fusion of the RAP1GAP and CELA3B genes. The fusion of the RAP1GAP and CELA3B genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAP1GAP-CELA3B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-RERE | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-REOR | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-REGO | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-REGR | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-REAQ | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-ORRE | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-OROR | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-ORGO | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-GORE | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-GOOR | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-GOGO | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-GOGR | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-GRRE | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-GROR | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-GRGO | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-GRGR | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-AQRE | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-AQOR | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-AQGO | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-AQGR | 20 (40 μL) | 200 μL |
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| RAP1GAP-CELA3B-20-AQAQ | 20 (40 μL) | 200 μL |
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RAP1GAP Gene Summary
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Gene Name: RAP1 GTPase Activating Protein
Chromosome: CHR1: 21922707 -21995856
Locus: 1p36.12
CELA3B Gene Summary
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]
Gene Name: Chymotrypsin Like Elastase Family Member 3B
Chromosome: CHR1: 22303417 -22315847
Locus: 1p36.12
Gene Diseases
The RAP1GAP CELA3B Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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