RAP1B-SCYL2 Fusion FISH Probe
The RAP1B-SCYL2 Fusion FISH Probe is used to confirm a fusion of the RAP1B and SCYL2 genes. The fusion of the RAP1B and SCYL2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAP1B-SCYL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-RERE | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-REOR | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-REGO | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-REGR | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-REAQ | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-ORRE | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-OROR | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-ORGO | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-GORE | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-GOOR | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-GOGO | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-GOGR | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-GRRE | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-GROR | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-GRGO | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-GRGR | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-AQRE | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-AQOR | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-AQGO | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-AQGR | 20 (40 μL) | 200 μL |
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| RAP1B-SCYL2-20-AQAQ | 20 (40 μL) | 200 μL |
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RAP1B Gene Summary
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]
Gene Name: RAP1B, Member Of RAS Oncogene Family
Chromosome: CHR12: 69004651 -69054374
Locus: 12q15
SCYL2 Gene Summary
The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Gene Name: SCY1 Like Pseudokinase 2
Chromosome: CHR12: 100661548 -100733914
Locus: 12q23.1
Gene Diseases
The RAP1B SCYL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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