RAP1A-CD2 Fusion FISH Probe
The RAP1A-CD2 Fusion FISH Probe is used to confirm a fusion of the RAP1A and CD2 genes. The fusion of the RAP1A and CD2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAP1A-CD2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-RERE | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-REOR | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-REGO | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-REGR | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-REAQ | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-ORRE | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-OROR | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-ORGO | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-GORE | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-GOOR | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-GOGO | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-GOGR | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-GRRE | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-GROR | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-GRGO | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-GRGR | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-AQRE | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-AQOR | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-AQGO | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-AQGR | 20 (40 μL) | 200 μL |
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| RAP1A-CD2-20-AQAQ | 20 (40 μL) | 200 μL |
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CD2 Gene Summary
The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016]
Gene Name: CD2 Molecule
Chromosome: CHR1: 117297085 -117311851
Locus: 1p13.1
RAP1A Gene Summary
This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: RAP1A, Member Of RAS Oncogene Family
Chromosome: CHR1: 112162404 -112256101
Locus: 1p13.2
Gene Diseases
The RAP1A CD2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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