RANBP2-BMP5 Fusion FISH Probe
The RANBP2-BMP5 Fusion FISH Probe is used to confirm a fusion of the RANBP2 and BMP5 genes. The fusion of the RANBP2 and BMP5 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RANBP2-BMP5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-RERE | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-REOR | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-REGO | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-REGR | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-REAQ | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-ORRE | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-OROR | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-ORGO | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-ORAQ | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-GORE | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-GOOR | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-GOGO | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-GOGR | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-GOAQ | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-GRRE | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-GROR | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-GRGO | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-GRGR | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-GRAQ | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-AQRE | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-AQOR | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-AQGO | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-AQGR | 20 (40 μL) | 200 μL |
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| RANBP2-BMP5-20-AQAQ | 20 (40 μL) | 200 μL |
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BMP5 Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016]
Gene Name: Bone Morphogenetic Protein 5
Chromosome: CHR6: 55620237 -55740375
Locus: 6p12.1
RANBP2 Gene Summary
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]
Gene Name: RAN Binding Protein 2
Chromosome: CHR2: 109335936 -109402267
Locus: 2q13
Gene Diseases
The RANBP2 BMP5 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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