RANBP10-LCAT Fusion FISH Probe
The RANBP10-LCAT Fusion FISH Probe is used to confirm a fusion of the RANBP10 and LCAT genes. The fusion of the RANBP10 and LCAT genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RANBP10-LCAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-RERE | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-REOR | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-REGO | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-REGR | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-REAQ | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-ORRE | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-OROR | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-ORGO | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-GORE | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-GOOR | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-GOGO | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-GOGR | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-GRRE | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-GROR | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-GRGO | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-GRGR | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-AQRE | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-AQOR | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-AQGO | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-AQGR | 20 (40 μL) | 200 μL |
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| RANBP10-LCAT-20-AQAQ | 20 (40 μL) | 200 μL |
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LCAT Gene Summary
This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008]
Gene Name: Lecithin-cholesterol Acyltransferase
Chromosome: CHR16: 67973786 -67978015
Locus: 16q22.1
RANBP10 Gene Summary
RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Gene Name: RAN Binding Protein 10
Chromosome: CHR16: 67757004 -67840555
Locus: 16q22.1
Gene Diseases
The RANBP10 LCAT Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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