RALY-CHMP4B Fusion FISH Probe
The RALY-CHMP4B Fusion FISH Probe is used to confirm a fusion of the RALY and CHMP4B genes. The fusion of the RALY and CHMP4B genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RALY-CHMP4B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-RERE | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-REOR | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-REGO | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-REGR | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-REAQ | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-ORRE | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-OROR | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-ORGO | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-ORAQ | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-GORE | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-GOOR | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-GOGO | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-GOGR | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-GOAQ | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-GRRE | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-GROR | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-GRGO | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-GRGR | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-GRAQ | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-AQRE | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-AQOR | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-AQGO | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-AQGR | 20 (40 μL) | 200 μL |
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| RALY-CHMP4B-20-AQAQ | 20 (40 μL) | 200 μL |
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RALY Gene Summary
This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Name: RALY Heterogeneous Nuclear Ribonucleoprotein
Chromosome: CHR20: 32581457 -32670991
Locus: 20q11.22
CHMP4B Gene Summary
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]
Gene Name: Charged Multivesicular Body Protein 4B
Chromosome: CHR20: 32399109 -32442173
Locus: 20q11.22
Gene Diseases
The RALY CHMP4B Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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